出生年月

1976.09

民族

汉族

籍贯

广东湛江

政治面貌

群众

毕业院校

浙江大学

专业

生物化工

学历

博研

学位

博士

电子邮箱

chenhuiying@zqu.edu.cn

通讯地址

肇庆学院实训中心507

联系电话

13717220716

所在院系

食品与制药工程学院

职称

副教授

担任职务

无

个人简介

博士，副教授，毕业于浙江大学化学与生物工程学院生物化工专业。2019-2020年在英国利兹大学开展基于基因组挖掘策略的天然活性物质的访学研究。近年来主持国家自然科学基金地区项目、广西自然科学基金面上项目、广西教育厅科研项目、肇庆学院高层次项目培育计划等项目。已发表SCI论文20余篇，其中以第一或通讯作者发表的论文15篇，主编教材2部，参编教材1部。目前主要从事通过计算机蛋白质设计技术理性设计与改造蛋白质分子的结构与功能方面的研究。

研究方向

1.蛋白质工程    2.食品酶的设计与改造   3.生物大数据分析

承担教学

承担《食品化学》、《食品工艺学》、《功能食品原理与评价》、《营养与健康大数据管理》等专业课程教学

科研项目

1. 国家自然科学基金委员会，21762015，海洋微紫青霉菌对重金属铬的生物吸附及其体内重金属抗性分子机制的研究，结题，主持。

2.广西科技厅，面上项目，2020GXNSFAA238037，紫色西番莲果皮花青素生物合成转录因子的筛选与功能分析，结题，主持。

3.广西教育厅，2017KY0251，海洋微紫青霉菌Penicillium janthinellum P1对Cr的吸附特性及机理的研究，结题，主持。

4.肇庆学院，GCCZK202409，转录因子PeMYB67调控西番莲果果实色泽形成的机制解析，在研，主持。

5.国家自然科学基金委员会， 22166015，酚、酯类污染物与G蛋白偶联雌激素受体结合机制及结构依赖性研究，在研，参加。

6. 国家自然科学基金委员会，31860251，西番莲酸性多糖改善2型糖尿病糖脂代谢紊乱的机制研究，结题，参与。

7. 国家自然科学基金委员会，31760472，甲硫氨酸亚砜还原酶（Msr）在荔枝采后衰老褐变中的作用机制研究，结题，参与。

学术论文

1.Ying Ni, Zeyang Cui, Zhiting Zhang, Huiying Chen*, Sheng Zhou. Genome-wide identification and expression analysis of anthocyanin synthesis-related R2R3-MYB gene family in purple passion fruit (Passiflora edulis). Materials Express, 2023, 13:467-481.

2.Shengnan Bao, Jiawei Mu, Pingchuan Yin, Huiying Chen*, Sheng Zhou. Exploration of anti-chromium mechanism of marine Penicillium janthinellum P1 through combinatorial transcriptomic analysis and WGCNA. Ecotoxicology and Environmental Safety, 2022, 233: xxx-xxx

3.Bin-Bin Chi, Ya-Nan Lu, Ping-Chuan Yin, Hong-Yan Liu, Hui-Ying Chen* and Yang Shan. Sequencing and Comparative Genomic Analysis of a Highly Metal-Tolerant Penicillium janthinellum P1 Provide Insights Into Its Metal Tolerance. Frontiers in Microbiology, 2021, 12: 1-12.

4.Xiaolian Lin,  Hongyan Liu,  Lin Tang,  Mengjie Shi,  Minhua Xu, Yipeng Huang, Zhongsheng Yi,  Huiying Chen*. Interaction between laccase and diethylstilbestrol based on multispectral and chromatography analyses. Journal of Molecular Recognition, 2022, 35(5): xxx-xxx

5.Huiying Chen*, Pingchuan Yin, Yanan Lu, Haiyun Li, Yang Shan. Bioinformatics Analysis Identified the Key Genes of Aspirin and Redox Damaged Yeast Cells, Pakistan journal of zoology, 2020, 52(5): 1841-1848.

6.Huiying Chen*, Yanan Lu, Pingchuan Yin, Xia Li, Yang Shan. Exploring the Mechanisms of Biosorption of Cr(VI) by Marine-derived Penicillium janthinellum P1, International Journal of Agriculture and Biology, 2019, 22(5): 913-920.

7.Xia Li, Feng Xiong, Yufeng Liu, Feifei Liu, Zaibin Hao, Huiying Chen*. Total fractionation and characterization of the water-soluble polysaccharides isolated from Enteromorpha intestinalis, International Journal of Biological Macromolecules, 2018, 111: 319-325.

8.Huiying Chen, Yixin Guan, Shanjing Yao*. A novel two-specie whole-cell immobilization system composed of marine-derived fungi and its application in wastewater treatment, Journal of Chemical Technology and Biotechnology, 2014, 89(11): 1733-1740.

9.CHEN Huiying, WANG Mingxia, SHEN Yubin, YAO Shanjing*. Optimization of Two-species Whole-cell Immobilization System Constructed with Marine-derived Fungi and Its Biological Degradation Ability. Chinese Journal of Chemical Engineering, 2014, 22(2): 187-192.

10.Hui-Ying Chen, Dong-Sheng Xue, Xiao-Yu Feng, Shan-Jing Yao*. Screening and Production of Ligninolytic Enzyme by a Marine-Derived Fungal Pestalotiopsis sp . J63, Applied Biochemsitry and Biotechnology, 2011, 165: 1754-1769.

11.Xia Li, Chengxin Liu, Jun Liang, Li Zhou, Jing Li, Huiying Chen, Tiemin Jiang, Yuan Guan, Hock Eng Khoo*. Antioxidative mechanisms and anticolitic potential of Desmodium styracifolium (Osb.) Merr. in DSS-induced colitic mice. Journal of Functional Foods, 2022, 93: xxx-xxx.

12.Luo Wei, Xu Jinglong, Chen Huiying, Zhang Huili, Yang Peilong, Yu Xiaobin. Synthesis of L-asparagine Catalyzed by a Novel Asparagine Synthase Coupled With an ATP Regeneration System. Frontiers in Bioengineering and Biotechnology, 2021, 9: 747404.

13.Yuan Guan, Hefei Sun, Huiying Chen, Yang Shan and Xia Li. Physicochemical characterization and the hypoglycemia effects of polysaccharide isolated from Passiflora edulis Sims peel. Food&Function, 2021, 12: 4221-4230.

14.Xia Li, Guozhu Zhang, Jing Li, Tiemin Jiang, Huiying Chen, Peijun Li, Yuan Guan. Degradation by Vc-H₂O₂, characterization and antioxidant activity of polysaccharides from Passiflora edulis peel. Journal of Food Processing and Preservation,  2021;00:e16074.

15.Xinyao Wen, Xia Li, Guiyang Cen, Shengyi Chen, Wen Lu, Huiying Chen, Zaibin Hao. Purification and Detection of Zwittermicin A from Bacillus thuringiensis G03A. International Journal of Agriculture and Biology, 2018, 20: 1071-1079.

16.FENG Xiaoyu, CHEN Huiying, Xue Dongsheng, Yao Shanjing*. Enhancement of Laccase Activity by Marine-derived Deuteromycete Pestalotiopsis sp. J63 with Agricultural Residues and Inducers. Chinese Journal of Chemical Engineering, 2013, 21(10): 1182-1189. 17.Dong-Sheng Xue, Hui-Yin Chen, Yi-Ran Ren, Shan-Jing Yao*.Enhancing the activity and thermostability of thermostable β-glucosidase from a marine Aspergillus niger at high salinity. Process Biochemistry, 2012, 47(4): 606-611.

18.Dong-Sheng Xue, Shan-Jing Yao*, Hui-Yin Chen, Dong-Qiang Lin, Yi-Xin Guan. Optimization of a Natural Medium for Cellulase by a Marine Aspergillus niger Using Response Surface Methodology. Applied Biochemistry and Biotechnology, 2012, 167: 1963-1972.

19.池彬彬, 倪莹, 陈慧英*, 刘红艳. 一株产果胶酶中度嗜盐菌Aspergillus aculeatus GLUT-01的鉴定及其产酶条件. 江苏农业科学, 2022, 50(2): 239-246.

20.唐琳, 刘红艳, 林晓莲, 卢慧, 陈慧英*. 结合光谱法和计算模拟分析 CYP3A4 酶与己烯雌酚的作用机制. 环境化学, 2021, 40(11): 1-8.

21.韩文, 陈海珊, 袁治豪, 秦舒琴, 陈慧英, 李典鹏, 李海云. 一株李氏禾内生细菌去除Cr(VI)的特性. 广西植物, 2019, (06): 729-736.

22.李霞, 熊峰, 覃献杏, 李家树, 崔萌佳, 郝再彬, 陈慧英*.  西番莲果皮多糖微波辅助提取工艺优化及其体外抗氧化性. 食品工业科技, 2018, (15): 141-146.

23.冯晓雨, 陈慧英, 薛栋升, 姚善泾*. 无机盐对海洋内生拟盘多毛孢菌J63产漆酶及漆酶脱色偶氮类染料的影响. 高校化学工程学报, 2013, (1): 90-95.

24.吴晓英*, 陈慧英, 林影. 溶菌酶涂膜保鲜杨梅的研究. 食品工业科技, 2005, 26(8): 157-160.

25.陈慧英, 吴晓英, 林影*. 溶菌酶分离纯化方法的研究新进展. 广东药学院学报, 2003, 19(4): 356-358.

获奖情况

授权专利

1.董新红, 殷菲胧, 乔沛, 陈慧英, 李静. 一种黄秋葵的保鲜方法. 授权号：ZL 2019 1  0612190.5

2.刘红艳, 张文强, 林晓莲, 陈慧英, 陆芽春, 单杨. 丁香醛作为漆酶降解已烯雌酚氧化还原介体的应用及其提高漆酶降解已烯雌酚降解率的方法. 授权号：ZL 2019 1 1082089.X